192-IgG is the antibody to the p75 neurotrophin receptor (p75NTR). The p75NTR, also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.

This fluorescent conjugate recognizes p75 receptor-positive cells in rat. It was prepared using mouse monoclonal antibody 192-IgG conjugated to Alexa 488. This product is routinely tested by flow cytometry.

Applications include flow cytometry, fluorescence spectroscopy, fluorescence anisotropy, epifluorescence microscopy, qualitative probe of binding to membrane-bound IgG‰Ûªs and the cytoskeleton.

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

Advanced Targeting Systems(ATS)位于美国加州圣地亚哥， 成立于1994年。 公司发起人Douglas Lappi和Ronald Wiley博士在实验室开发出先进的分子神经外科学研究技术。ATS主要生产用于科研和药物研发的靶向试剂，公司在疼痛和药物转运的研究及临床治疗的两个产品已获专利保护。目前，产品包括靶向毒素 (可提供基底前脑胆碱能神经元、去甲肾上腺素能和肾上腺素能神经元、巨噬细胞和小胶质细胞的特异性损伤试剂等)、二抗生物素、神经元抗体、神经递质抗体、蛋白质和荧光结合物、免疫毒素对照等。