Adrenocorticotropic hormone (also known as corticotrophin) is a peptide hormone secreted by the anterior pituitary gland.  It is a stress-related hormone that promotes the production and release of cortisol, as well as playing a role in circadian rhythm.  In the brain, ACTH receptors are found primarily on adrenocortical cells in the adrenal cortex.  Receptors are also expressed in osteoblasts. The ACTH-SAP conjugate will eliminate cells expressing the ACTH receptor.  This conjugate can be used to study acute multiple sclerosis, rheumatoid arthritis, allergic conjunctivitis, and ulcerative colitis, among other conditions.

ACTH-SAP eliminates cells expressing the ACTH receptor.

This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.

*Data subject to review by the scientific team at ATS. See complete details here.

Advanced Targeting Systems(ATS)位于美国加州圣地亚哥， 成立于1994年。 公司发起人Douglas Lappi和Ronald Wiley博士在实验室开发出先进的分子神经外科学研究技术。ATS主要生产用于科研和药物研发的靶向试剂，公司在疼痛和药物转运的研究及临床治疗的两个产品已获专利保护。目前，产品包括靶向毒素 (可提供基底前脑胆碱能神经元、去甲肾上腺素能和肾上腺素能神经元、巨噬细胞和小胶质细胞的特异性损伤试剂等)、二抗生物素、神经元抗体、神经递质抗体、蛋白质和荧光结合物、免疫毒素对照等。