Leptin is a 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.

Leptin Rat Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and having a molecular mass of 16 kDa. The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Val-Pro-Ile-His. The protein was lyophilized from a concentrated (1 mg/ml) solution with 0.0045mM NaHCO3. It is purified by proprietary chromatographic techniques. Biological activity  is evidenced by inducing proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Protein quantitation was determined by UV spectroscopy at 280 nm and analysis by RP-HPLC using a calibrated solution of Leptin Rat as a reference standard. It has been determined that Leptin Rat is more than 95% pure by analysis with SEC-HPLC and SDS-PAGE.

Advanced Targeting Systems(ATS)位于美国加州圣地亚哥， 成立于1994年。 公司发起人Douglas Lappi和Ronald Wiley博士在实验室开发出先进的分子神经外科学研究技术。ATS主要生产用于科研和药物研发的靶向试剂，公司在疼痛和药物转运的研究及临床治疗的两个产品已获专利保护。目前，产品包括靶向毒素 (可提供基底前脑胆碱能神经元、去甲肾上腺素能和肾上腺素能神经元、巨噬细胞和小胶质细胞的特异性损伤试剂等)、二抗生物素、神经元抗体、神经递质抗体、蛋白质和荧光结合物、免疫毒素对照等。